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Duncan Howie

Dr Duncan Howie, Stipendiary Lecturer in pre-clinical Pathology

Dr Duncan Howie, Stipendiary Lecturer in pre-clinical Pathology

A Research Scientist, Duncan Howie is a member of the Therapeutic Immunology Group at the Sir William Dunn School of Pathology.

Contact Duncan Medicine at Wadham

Duncan trained in Experimental Pathology and Immunology at the University of Glasgow (BSc), St Bartholomews, University of London (PhD) and Harvard University.

He is engaged in research designed to understand the molecular mechanisms by which T lymphocytes with regulatory function are generated and maintained during immunological tolerance. In general terms he is investigating how intracellular signalling initiated through lymphocyte surface receptors controls cell decisions and ultimately functional consequences in immune-mediated pathological states. He uses a combination of transcriptional analysis combined with comparative proteomics and downstream molecular and cellular model analyses.

Duncan’s teaching includes immunology lectures for first year BM, BCh (1st BM part 1); Pre-clinical Pathology to Second year BM, BCh (1st part 2); and intercollegiate teaching in infection and immunity to third year FHS. He is an examiner for the Honours Schools in Medicine at Oxford University.

Contact

Dr Duncan Howie
duncan.howie@path.ox.ac.uk

Selected publications

Regateiro FS, Howie D, Cobbold  SP, and Waldmann H. TGF-β in  transplantation tolerance Current Opinion in Immunology. August 2011 (In press)

Graca L, Chen TC, Le Moine A, Cobbold SP, Howie D, Waldmann H. Dominant tolerance: activation thresholds for peripheral generation ofregulatory T cells. Trends Immunol. 2005 Mar;26(3):130-5.

Morra M, Howie D, Grande MS, Sayos J, Wang N, Wu C, et al. X-linked lymphoproliferative disease; a progressive immunodeficiency. Annual Rev. Immunol 2001; 19:657-682.

Howie D, Sayos J, Terhorst C, Morra M. The gene defective in X-linked lymphoproliferative disease controls T cell dependent immune surveillance against Epstein-Barr virus. Curr Opin Immunol 2000; 12:474-478.

Howie D, MacDonald TT. The ontogeny of T lymphocytes within the human intestine. Sanderson IR, Walker WA eds: Development of the Gastrointestinal tract. Toronto, BC Decker, 1998.


Chen Y, Adams E, Regateiro FS, Vaux DJ, Betz A,. Andersen KG, Waldmann H, Howie D Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering. Eur J Immunol. 2012 In press: DOI: 10.1002/eji.201142207

Agorogiannis EI, Regateiro FS, Howie D, Waldmann H, Cobbold SP. Th17 Cells Induce a Distinct Graft Rejection Response That Does Not Require IL-17A. Am J Transplant. 2012

Regateiro FS, Howie D, Nolan KF, Agorogiannis EI, Greaves DR, Cobbold SP, Waldmann H. Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β. Eur J Immunol. 2011 Jul 19. (In press)

Condamine T, Le Texier L, Howie D, Lavault A, Hill M, Halary F, Cobbold S, Waldmann H, Cuturi MC, Chiffoleau E. Tmem176B and Tmem176A are associated with the immature state of dendritic cells. J Leukoc Biol. 2010 Sep;88(3):507-15

Howie D, Nolan KF, Daley S, Butterfield E, Adams E, Garcia-Rueda H, Thompson C, Saunders NJ, Cobbold SP, Tone Y, Tone M, Waldmann H. MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation. J Immunol. 2009 Oct 1;183(7):4197-204

Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, Fairchild PJ, Mellor AL, Ron D, Waldmann H. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12055-60

Howie D, Laroux FS, Morra M, Satoskar AR, Rosas LE, Faubion WA, Julien A, Rietdijk S, Coyle AJ, Fraser C, Terhorst C. Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol. 2005 May 15;174(10):5931-5.

Howie D, Sayos J, Guirado M, Simarro M, Sancho J and Terhorst C. Molecular dissection of the signaling and co-stimulatory functions of CD150 (SLAM). Blood 2002; 99(3):957-65.

Howie D, Okamoto S, Rietdijk S, Clarke K, Wang N, Gullo C, Bruggeman JP, Manning S, Coyle AJ,Greenfield E, Kuchroo V and Terhorst C. The role of SAP in murine CD150 (SLAM)-mediated T cell proliferation and Interferon gamma production. Blood 2002;100(8):2899-2907

Howie D, Spencer J, DeLord D, Pitzalis C, Wathen NC, Dogan A, et al. Extrathymic T cell differentiation of the human intestine early in life. J Immunol. 1998; 161:L5862-5872.