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Perry Blackshear

Perry J Blackshear, Visiting Fellow

Perry Blackshear is a Keeley Visiting Fellow at Wadham for the 2019-2020 academic year

He is ordinarily a Senior Investigator at the National Institute of Environmental Health Sciences (NIEHS), and Consulting Professor of Medicine and Adjunct Professor of Biochemistry at Duke University, both in Durham, North Carolina, USA.

Perry’s undergraduate education was at the University of Minnesota, followed by three years at Trinity College, Oxford, from which he received a DPhil in biochemistry.  He finished medical training at Harvard Medical School and Massachusetts General Hospital in internal medicine and endocrinology, and then moved to Duke University Medical Center in Durham, NC, USA, where he became a Professor of Medicine and of Biochemistry.  He moved to the NIEHS in 1994 as the Clinical Director of that Institute, and after several other administrative roles he resumed full time research in 2010.     

His current studies focus on the regulation of gene expression at the level of post-transcriptional events, particularly the effects of RNA binding proteins in controlling translation and decay rates of cytoplasmic messenger RNAs.  His work has led to new insights into the importance of post-transcriptional control in gene expression in several physiological systems, particularly innate immunity and the hematopoietic system. This work has suggested potential therapeutic approaches to immune and inflammatory diseases and hematopoietic disorders.  While in Oxford, he hopes to extend this research into the innate immune system in the Department of Biochemistry. 

Selected recent publications

Lai, WS, Stumpo, DJ, Wells, ML, Gruzdev, A, Hicks, SN, Nicholson, CO, Yang, Z, Faccio, R, Webster, MW, Passmore, LA and Blackshear, PJ.  2019.  Importance of the conserved carboxyl-terminal CNOT1 binding domain to tristetraprolin (TTP) activity in vivo. Mol Cell Biol, 2019 Jun 13;39(13). pii: e00029-19.

Lai, WS, Wells, ML, Perera, L and Blackshear, PJ.  2019. The tandem zinc finger RNA binding domain of members of the tristetraprolin (TTP) protein family.  Wiley Interdiscip Rev RNA. 2019 Mar 12:e1531.

Lai, WS, Stumpo, DJ, Qiu, L, Faccio, R, and Blackshear, PJ.  2018.  A knock-in tristetraprolin (TTP) zinc finger point mutation in mice:  Comparison with complete TTP deficiency.  Mol Cell Biol, 38:e00488-17.

Fu, M and Blackshear, PJ.  RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins.  2017.  Nature Reviews Immunology, 17:130-143.  

Wells, ML, Perera, L and Blackshear, PJ.  An ancient family of RNA-binding proteins: Still important!.  2017. Trends Biochem Sci,1328:1-12. 

Patial, S, Curtis, AD II, Lai, WS, Stumpo, DJ, Hill, GD, Flake, GP, Mannie, MD and Blackshear, PJ.  Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.  2016.  Proc Natl Acad Sci USA, 113:1865-1870.

Stumpo, DJ, Trempus, CS, Tucker, CJ, Huang, W, Li, L, Kluckman, K, Bortner, DM and Blackshear, PJ.  Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism.  2016.  Development, 143:1424-1433. 

Patial, S and Blackshear, PJ.  Tristetraprolin (TTP) as a therapeutic target in inflammatory disease.  2016. Trends Pharmacol Sci, 37:811-821.

Qiu, L-Q, Lai, WS, Bradbury, A, Zeldin, DC, and Blackshear, PJ. Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to pro-inflammatory stimuli.  2015. J Leukocyte Biol, 97:723-36. 

Wells, ML, Hicks, SN, Perera, L and Blackshear, PJ.  Functional equivalence of an evolutionarily conserved RNA binding module. 2015.  J Biol Chem, 290:24413-24423.