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Matthew Langton

Dr Matthew Langton, RJP Williams Junior Research Fellow in Chemistry

Matthew is a Royal Society University Research Fellow in the Department of Chemistry and the RJP Williams Junior Research Fellow at Wadham College.

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His research interests are at the interface of synthetic supramolecular chemistry, biological chemistry and nanotechnology. Supramolecular chemistry is the field of chemistry that concerns intermolecular interactions: understanding these is crucial to understanding many biological processes, whilst controlling them in artificial systems enables new molecular devices to be engineered for a wide range of applications. 

Matthew's research seeks in particular to design, synthesise and study functional supramolecular devices which can interface with biological systems. One particular avenue of his work is in designing synthetic molecular machines that function within lipid bilayer membranes of artificial cells. Molecular machines are molecules in which nano-mechanical motion can be controlled and exploited to carry out a specific task. His research is developing these nano-scale machines that respond to external signals (such as chemical or light), and which can be used to control different properties and functions of cell-like systems.

Selected Publications

Triggered release from lipid bilayer vesicles by an artificial transmembrane signal transduction system; M. J. Langton, L. M. Scriven, N. H. Williams and C. A. Hunter, J. Am. Chem. Soc., 2017, 139, 15768–15773

Recognition-controlled membrane translocation for signal transduction across lipid bilayers; M. J. Langton, N. H. Williams and C. A. Hunter, J. Am. Chem. Soc., 2017, 139, 6461–6466

Controlled membrane translocation provides a mechanism for signal transduction and amplification; M. J. Langton, F. Keymeulen, M. Ciaccia, N. H. Williams and C. A. Hunter, Nat. Chem.2017, 9, 426-430. 

Anion recognition in water: recent advances from a supramolecular and macromolecular perspective; M. J. Langton, C. J. Serpell and P. D. Beer, Angew. Chem. Int. Ed., 2016, 55, 1974–1987

Halogen bonding in water results in enhanced anion recognition in acyclic and rotaxane hosts; M. J. Langton, S. W. Robinson, I. Marques, V. Felix and P. D. Beer, Nat. Chem., 2014, 6, 1039-1043. 

Nitrite-Templated Synthesis of Lanthanide-Containing [2]Rotaxanes for Anion Sensing; M. J. Langton, O. A. Blackburn, T. Lang, S. Faulkner and P. D. Beer, Angew. Chem. Int. Ed., 2014, 53, 11463-11466.